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Medycyna konwencjonalna - Statyny indukują kalcyfikację
Witold Jarmolowicz - Pon Gru 06, 2021 11:19
Temat postu: Statyny indukują kalcyfikację
| Cytat: | Statin-induced calcification in human mesenchymal stem cells is cell death related
Statyny indukują kalcyfikację
Conflicting opinions in the statin literature stem from the fact
that the effects may vary depending on species, the type of statins used, and most importantly the applied concentration.
We examined a range of concentrations and found that statins at 1 mikro-M or lower concentration decreased calcification rate compared with non-induced control, together with decreased ALP activity. Below 1 mikro-M statins did not exert any adverse effect on cell viability; the apoptotic staining was negative. This is in concert with the antiapoptotic
effect of lovastatin at low concentrations [36].
Higher statin concentration (5 mikro-M) caused higher calcification rate, but this was coupled with – and most probably caused by – extensive cell death. Hence, these compounds should be used cautiously at high concentrations, although the toxic effect may be alleviated
in vivo. Statins may still increase bone mass through inhibition of bone resorption, or increasing fully mature osteoblast’s activity via BMP-2, but they are not able to differentiate human MSCs into osteoblasts.
Therefore, simvastatin and lovastatin are not suitable for bone tissue engineering applications as osteogenic factors due to their long-term toxic effect on MSCs (mesenchymal stem cells).
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