http://www.ncbi.nlm.nih.gov/pubmed/16205932 Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
Barel A1, Calomme M, Timchenko A, De Paepe K, Demeester N, Rogiers V, Clarys P, Vanden Berghe D.
Arch Dermatol Res. 2006 Apr;297(10):481. Dosage error in article text.
Arch Dermatol Res. 2006 Feb;297(8):381. Paepe, K De [corrected to De Paepe, K]
Abstract
Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, "none=0, severe=3") brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: -16%; Rm: -19%; Rz: -8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.
http://www.ncbi.nlm.nih.g...les/PMC3546016/ Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy
Lela Munjas Jurkić,1 Ivica Cepanec,2 Sandra Kraljević Pavelić,corresponding author1 and Krešimir Pavelić1
Conclusion
In conclusion, we believe that ortho-silicic acid (H4SiO4) might be a prominent therapeutic agent in humans. Some potential therapeutic and biological effects on bone formation and bone density, Alzheimer disease, immunodeficiency, skin, hair, and nails condition, as well as on tumour growth, have already been documented and are critically discussed in the presented paper. Acid forms of ortho-silicic acid include: choline-chloride-stabilized ortho-silicic acid (ch-OSA) as a specific pharmaceutical formulation of H4SiO4, simple water soluble silicate salts such as sodium silicate (E550; Na2SiO3) or potassium silicate (E560; K2SiO3), and certain water-insoluble forms that, upon contact with stomach juice (HCl), release small, but biologically significant amounts of ortho-silicic acid. The latter involves: colloidal silicic acid (hydrated silica gel), amorphous silicon dioxide (E551), certain types of zeolites such as zeolite A (sodium aluminosilicate, E554; potassium aluminosilicate, E555; calcium aluminosilicate, E556), and the natural zeolite clinoptilolite. However, for some of the above-proposed therapeutic perspectives of both ortho-silicic acid and ortho-silicic acid -releasing derivatives, additional insights into biological mechanisms of action and larger studies on both animals and humans are required.
17 Bowen HJM, Peggs A. Determination of the silicon content of food. J Sci Food Agric. 1984;35:1225–1229. doi: 10.1002/jsfa.2740351114. http://dx.doi.org/10.1002%2Fjsfa.2740351114
Generally, silicon is abundantly present in foods derived from plants such as: cereals, oats, barley, white wheat flour, and polished rice. In contrast, silicon levels are lower in animal foods including meat or dairy products. Furthermore, silicon is present in drinking waters, mineral waters, and in beer as well
http://www.ncbi.nlm.nih.g...stid969510title
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Barodon
Nonspecific immunostimulator BARODON. The composition of the anionic
mineral complex BARODON is as follows: 600 g of sodium metasilicate
(Na2SiO3 commercialized disodium trioxosilicate extracted from plants; Nederland
B.V., The Netherlands), 300 g of potassium carbonate (K2CO3), 9 g of
sodium carbonate (Na2CO3), 9 g of sodium borate (Na2B4O7), 900 g of sucrose
(C12H22O11), 10 mg of silver nitrate (AgNO3), 30 mg of sodium chloride (NaCl),
and 120 mg of sodium thiosulfate (Na2S2O3) dissolved in a total of 1,000 ml of
water. The product was patented in the United States (patent no. 6,447,810 B1
and 6,673,375 B2) and in Korea (patent no. 0331952), as well as in the Republic
of South Africa (patent no. 2003/3337) (10, 11, 12, 13). The specific gravity of the
product is 1.43, and the pH is 13.5. Barodon-biogenic feed is 10% diluent of
BARODON in water, and Omolene feed is equine fermented feed composed of
0.05% BARODON and 99.5% other ingredients generally used for feed (soybean
hulls, wheat hulls, molasses, corn, soybean meal, wheat, gluten feed, salt,
calcium carbonate, and pura mix).
Po prostu szkło wodne z niewielkim dodatkiem boraksu.
JW
Barodon-biogenic feed is 10% diluent of BARODON in water, and Omolene feed is equine fermented feed composed of 0.05% BARODON and 99.5% other ingredients
Na 500 kg konia przypada 4000 g odżywki Omolene z dodatkiem 0,05% Barodonu, krzemowego preparatu. Zatem koń dostaje 300 mg krzemu.
Odnosząc to do 100 kg człowieka, wychodzi 50 mg krzemu w postaci szkła wodnego dodanego do jakiejś karmy, żeby mu nie spaliło gardła, bo szkło wodne ma pH-13
JW
Kelsay JL, Behall KM, Prather ES. Effect of fiber from fruits and vegetables on metabolic responses of human subjects. II. Calcium, magnesium, iron, and silicon balances. The American Journal of Clinical Nutrition. 1979; 32:1876–1880. [PubMed: 474478]
Fibre—Kelsay et al. (46), demonstrated that a high fibre diet (fruit and vegetables) reduces the gastrointestinal uptake of minerals, including Si. Urinary excretion of Si was 35% compared with 58% from a low fibre diet; while faecal excretion was 97% and 67% respectively. Both diets, however, produced a negative Si balance, although, this was more negative with the high fibre diet (−14.6 mg/day compared with −3.5 mg/day).
Wychodzi na to, że zarówno niskobłonnikowe jak i wysokobłonnikowe pożywienie zmniejsza wchłanianie soli mineralnych, z tym, że wysokobłonnikowe utrudnia absorpcję minerałów bardziej . Nie należy z niczym przesadzać.
JW
Odnosząc to do 100 kg człowieka, wychodzi 50 mg krzemu w postaci szkła wodnego dodanego do jakiejś karmy, żeby mu nie spaliło gardła, bo szkło wodne ma pH-13
JW
Jeszcze raz, szkło wodne jest żrące jak soda kaustyczna.
Żeby się suplementować tym wynalazkiem, podobnym do zarejestrowanego preparatu Barodon, 50 mg krzemu jest zawarte w 600 mg szkła wodnego czyli w jednej dziesiątej części łyżeczki do herbaty rozpuszczonej w 1 litrze wody Lub innego wodnego płynu. To wręcz śladowe ilości, jedna dziesiąta łyżeczki w litrze wody, albo jedna cała łyżeczka do herbaty na dziesięć litrów.
Dlaczego tak rozcieńczać? Po pierwsze, żeby nie przeżarło krtani.
Po drugie, bo kwas krzemowy, który powstaje z krzemianu sodu w wyniku hydrolizy, jest stabilny tylko w rozcieńczeniu do 2 mmol krzemu na litr, tzn. 420 mg krzemianu sodu lub 600 mg szkła wodnego. Powyżej stężenia 2 mmol kwas krzemowy ulega samorzutnej polimeryzacji do nierozpuszczalnego żelu w wodnym środowisku pH=7. Powyżej 2 mmol kwas krzemowy jest stabilny tylko w środowisku silnie kwasowym lub zasadowym, absolutnie nie obojętnym, dlatego szkło wodne pH-13 jest stabilne, ale kompletnie nie nadaje się do picia, bo żrące. Podobnie, kwas krzemowy jest stabilny w roztworach o kwasowości poniżej 2,5 pH, czyli np. w żołądku.
Dlatego te preparaty krzemowe są wściekle drogie, bo trudno uzyskać suplement stężonego krzemu, który zachował rozpuszczalność i przyswajalność dłużej, niż kilka dni.
JW
Klasycznym preparatem krzemowym jest amerykański Biosil.
Po pierwsze jest drogi, miesięczna suplementacja kosztuje około 100 PLN.
Biosil
Jedna kropla zawiera 1 mg krzemu, dzienna dawka to dwa razy po 5 kropli zawierających 5 mg krzemu w postaci kwasu ortokrzemowego oraz 100 mg choliny w postaci chlorku, jako stabilizatora. Stąd wynika, że stężenie krzemu w Biosilu wynosi 2%
Ze względu na stabilność krzemu, Biosil jest kwaśny, ma pH-2 i dlatego należy dawkę wkroplić do 1/4 szklanki wody.
Lub 1/4 filiżanki wody (cup), jeżeli ktoś woli jednostki amerykańskie objętości.
Dzienna dawka 10 mg krzemu z Biosilu to asekuracyjnie niska ilość, ponieważ przyjmuje się dzienne zapotrzebowanie na krzem jako 20-50 mg.
Do tego przydałby się bor w ilości połowy krzemu, którego w Biosilu nie ma.
Polski preparat Silor+B zawiera krzem i bor, dzienna dawka dostarcza już więcej, bo 13 mg krzemu i 7 mg boru. Wszakże, podobnie jak Biosil, tani nie jest.
Alternatywą jest mieszanina krzemianu sodu, kwasu fosforowego, kwasu borowego, kwasu cytrynowego, ale jako, że substraty są bardzo żrące nie podamy szczegółowego przepisu.
JW
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