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tutaj artykuł o Lactobacillusie Rhamnosusie GG i o tym, że wiele innych probiotyków ma znikomą korzyść dla organizmu -
"Lactobacillus Rhamnosus GG
Powerful Probiotic Strengthens Digestion and Immunity
By Rose Young, MS, RN
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Many individuals concerned about digestive health are familiar with the good bacteria known as probiotics. The probiotic Lactobacillus rhamnosus GG (LGG) is especially well researched for its positive effects on the intestinal tract. Yet, discussions about probiotics would not be complete without mentioning one of their lesser known properties: building a strong immune system.
Although most people think of blood cells as powering the immune system, the gut is actually the body"s largest immune organ. Research has demonstrated that certain probiotic bacteria can influence the human intestinal cells" production of secretory IgA and intestinal mucus, both of which serve as an immunological envelope stopping harmful organisms from entering the body through the bowel wall.
When we are born our gastrointestinal tracts are sterile, but throughout the first year of life, they become populated with bacteria. During that time, the environment in which we live and the nutrients we consume influence the types of bacteria our bodies recognize as "normal" and this then directs how our immune system develops. Consequently, from the moment we are born, our intestinal tracts play a vital role in how we will ultimately cope with the dangerous bacteria and viruses our bodies are exposed to daily.
The hygiene hypothesis, a relatively new notion in the world of medicine, proposes that a lack of adequate immune system exposure early in life is in part related to the increasing incidence of asthma and various allergic disorders. This observation grew from the fact that researchers recognized that children in daycares and those born in less sanitary environments had a much lower incidence of allergic conditions. There"s even some indication that exposure to abnormal gut bacteria for the first year of life may be associated with irritable bowel syndrome as an adult.
In this article, I will explain how the probiotic LGG can help strengthen not only digestive health but also the immune system. Furthermore, I will explain why taking the wrong strain of probiotic can be just as useless as not taking any probiotics at all.
Nourishing Our Digestive Systems
LGG"s most well known effects revolve around its ability to influence digestive tract health. As a pediatric nurse practitioner at the University of Nebraska Medical Center, I became involved in a number of research projects in the 1990s that investigated the gastrointestinal effects of LGG. One of our most interesting studies involved LGG"s effects on antibiotic-associated diarrhea in children. A team of investigators and myself randomized the children (ages newborn to 12 years) who were receiving antibiotics into two groups. One group received the antibiotics with a placebo, the other group received the antibiotics with LGG. The results of our placebo-controlled, randomized study indicated that children who received LGG not only had fewer episodes of diarrhea but their stools were less likely to become loose compared to the children who did not receive the probiotic.
The success of our first study led to other studies that investigated how LGG influenced community-acquired viral diarrhea in infants attending daycare. In a multi-centered trial in European countries, researchers investigated LGG"s effects on viral diarrhea because they knew that other researchers had obtained similar results with LGG in children suffering from diarrhea in third-world countries. These studies indicated that LGG was particularly helpful with rotavirus infections, a common cause of diarrhea, by decreasing the duration of loose stools by at least one day.1
Recently, a medical literature review confirmed these results. The review, which looked at randomized, double-blind, placebo-controlled trials, found that use of probiotics was associated with a significantly reduced risk of diarrhea lasting three days, but only Lactobacillus GG showed a consistent effect. LGG significantly reduced the duration of diarrhea when compared with placebo, particularly in rotavirus-caused diarrhea.2 Other studies also have demonstrated that giving LGG to healthy children is beneficial in preventing the acquisition of viral diarrhea. LGG was not effective in bacterial diarrhea, however, although other probiotic strains may be useful in this case.
Studies in adults have reached similar conclusions. In subjects taking antibiotics to eradicate the ulcer-causing bacterium Helicobacter pylori, LGG significantly reduced side effects such as bloating, diarrhea and taste disturbances that occur with antibiotic therapy.3
In subjects with ulcerative colitis who underwent a proctocolectomy (the surgical removal of the rectum and all or part of the colon), Lactobacillus rhamnosus GG reduced the occurrence of a typical complication known as pouchitis. This complication occurs when the artificially created pouch becomes acutely inflamed. LGG had, according to the researchers, "a significant clinical benefit" in patients suffering from this condition.4
LGG and Immunity
Lactobacillus rhamnosus GG has been studied extensively for its immune-enhancing properties. LGG can influence immune responses both specifically by stimulating antibody production and nonspecifically by enhancing phagocytosis, one of the processes by which the body destroys foreign invaders. LGG also modifies production of cytokines, proteins important in the immune response.
In a double-blind, crossover study, researchers investigated whether LGG could affect the immune system in dairy-hypersensitive adults and healthy adults not sensitive to dairy. Both dairy-sensitive and dairy-non-sensitive subjects were given either milk alone or milk with LGG. When the dairy-sensitive subjects were given milk without the probiotic, the milk-induced an inflammatory response. However, LGG eliminated this inflammatory response in the milk-sensitive subjects to a significant degree. Moreover, in the healthy subjects, in whom milk did not trigger an inflammatory response, the LGG stimulated the immune system.5
Studies also have investigated LGG"s ability to improve the efficacy of various vaccines. One group of researchers set out to study whether and how LGG affects the immune response following a booster polio vaccination as well as how LGG influences infections outside of the gastrointestinal tract in healthy adults. In the randomized, double-blind, placebo-controlled study, 64 volunteers consumed either milk without a probiotic or milk with LGG or Lactobacillus acidophilus for five weeks. In the second week of the study, subjects were vaccinated against polio.
In subjects given the probiotics, there was an increase in poliovirus neutralizing antibodies. In probiotic-treated subjects, there was also an increase in the immunoglobulins specific to poliovirus. The maximum increase for immunoglobulins was up to 4-times higher in subjects who consumed the probiotics compared to those who consumed the placebo.6 A similar study done in children also demonstrated an improved response to rotavirus vaccine when the children were concurrently receiving LGG.7
According to the researchers, "Probiotics induce an immunologic response that may provide enhanced systemic protection of cells from virus infections by increasing production of virus neutralizing antibodies."
New science has found that LGG can affect the immune system in a variety of populations, and that it can affect the health of parts of the body that are far removed from the intestinal tract. Building on past studies that looked at probiotics" ability to reduce intestinal inflammation in children with cystic fibrosis, researchers in Italy conducted a randomized, placebo-controlled, cross-over study. The trial included 19 children with cystic fibrosis who received LGG in oral rehydration solution for 6 months and then shifted to a plain oral rehydration solution for 6 months. The other group of subjects received the plain oral rehydration solution first and then shifted to LGG. When the patients were given LGG, they experienced reduced pulmonary exacerbations and hospital admissions compared to when they were taking the oral rehydration solution without the LGG. Patients given LGG also experienced an improvement in the forced expiratory volume (a measurement of lung health), and an increase in body weight.8
The researchers concluded that the results "suggest that probiotics may delay respiratory impairment and that a relationship exists between intestinal and pulmonary inflammation."
Choosing the Best Probiotic Strain
Probiotic products are often lumped under the same category, but it has become apparent that it actually does matter which probiotic strain an individual consumes. Human-derived probiotics, such as Lactobacillus rhamnosus GG, are considered superior, since human-derived products tend to be more compatible with our bodies. Certain non-human probiotics may adversely stimulate the immune system because they"re perceived as foreign to the body. In some cases low-level adverse stimulation is good, such as noted with the mechanism of action of normal vaccinations. However, a person never really knows when the immune system might be stimulated in the wrong direction.
It"s also important to recognize that even though LGG is a human-derived probiotic, its origin is from no particular individual. When we were conducting the studies on LGG, quite a few people would ask, "How do you know that the person this came from was really a healthy person?" We had to explain that the strain is identical to that found in humans, but its commercial production occurs under sterile laboratory conditions and it"s continually monitored to know that it hasn"t mutated.
So much scientific evidence exists to support LGG"s effects that the government is convinced that further studies on LGG are worth pursuing. Currently, the National Center for Complementary and Alternative Medicine, a division of the National Institute of Health (NIH), is endorsing a study to determine if LGG improves immune response to the flu vaccine. They have also funded another in-progress study that is examining whether giving LGG to pregnant mothers with a family history of asthma reduces the occurrence of asthma in their infants.
Clearly, the intestinal tract is in the driver"s seat when it comes to maintaining not only digestive health, but also a healthy immune system. In this world of processed, sterile food, where we are not giving our good gut bacteria all the nourishment they need, it is therefore prudent to help the intestinal tract maintain a healthy balance by consuming LGG.
Rose Young, MS, RN
Rose Young is a pediatric nurse practitioner at Boy"s Town National Research Hospital in Omaha, Nebraska. She was a member of the University of Nebraska Medical Center team who conducted a number of studies on Lactobaccilus rhamnosus (LGG)."
Matti, pomogły Ci probiotyki? Ja tak samo w UK kupowałem tanie probiotyki. Łykałem po 5-6 do każdego posiłku i mogłem jeść wszystko. Ale jak tylko zmniejszyłem dawkę probiotyków, np. po 2 miesiącach, to problemy wracały. Więc to było tylko chwilowe działanie. Wymyśliłem sobie takie wytłumaczenie, że jeśli nie mam, albo mam za mało potrzebnych enzymów, to niestrawione jedzenie fermentuje w jelitach. Jeśli jem dużo probiotyków, to chwilowo mam za dużo więcej dobrych bakterii, które nie powodują takiego fermentowania. Ale te bakterie nie utrzymają się w jelitach w takiej dużej ilości bez podawania odpowiednich dawek probiotyków (a może utrzymałyby się, ale nie mogą wywalczyć sobie miejsca).
Kiedyś myślałem, że mam coś nie tak z florą jelitową. A teraz myślę, że z florą jest wszystko w porządku, ale coś namieszane z enzymami... Same bakterie chyba nie pomogą, to jest tylko takie usuwanie skutków.
Trzeba by się rozwiedzieć jak wygląda ta flora bakteryjna. Czy to jest tylko jeden acidofilus czy tam jeszcze drugi, czy może jest tego więcej.
TO normalne że jak się przestanie łykać tabletki to po jakimś czasie flora "wygasa". Te dobre bakterie mają to do siebie że giną po jakimś okresie. Zresztą nie tylko one.
Na pewno łykanie bakterii nie jest normalne fijzjologiczne. Stosowanie w sposób leczniczy ma jakiś sens u ludzi u których ta flora została zniszczona. Ale również badania mówią o tym że ta flora powinna się przy sprzyjających warunkach zwyczajnie odnowić. Lepiej chyba jest po prostu zjadać regularnie kiszonki. Poza tym należy uwzględnić fakt że jak się łyka bakterie to powinno się do tego dostarczyć pożywkę. Jeżeli będziemy wcinać samo mięcho i tłuszcz i do tego stosować bakterie to wątpię aby one dawały radę.
A więc wniosek jest moim zdaniem taki - co sprawia że flora jest niezrównoważona. Stosowanie tabletek ewentualnie jes do przyjęcia jako jednorazowa kuracja na zasadzie doprowadzenia do porządku albo inaczej mówiąc aby jelita zaskoczyły. No powiedzmy że jeszcze w przypadku kiedy w organizmie toczą się jakieś patologiczne procesy, gdzie potrzeba przechylić wagę tak długo jak to jest potrzebne dla regeneracji, wtedy ew. do przyjęcia jest dłuższa suplementacja. Z tym że tutaj też sprawę powinny załatwiać naturalne produkty.
A dalej to już tak jak piszesz kwestia trawienia, enzymy, a więc wątroba i trzustka. Również należy zwrócić uwagę na żołądek.
Ostatnio zmieniony przez rakash Śro Maj 04, 2011 14:57, w całości zmieniany 3 razy
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